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SS-31 peptide is a cardiolipin peroxidase inhibitor and mitochondrial targeting peptide. It improves left ventricular and mitochondrial function. SS-31 peptide reduces mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It protects iHTM and GTM cells from sustained oxidative stress induced by H2O2. Phase II clinical trials for the treatment of chronic heart failure and mitochondrial myopathy are ongoing.
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